Women needed for cardiovascular study

(Aug. 31, 2009) Healthy women are needed to participate in a study that will investigate what causes arteries to become unhealthy with menopause and the loss of estrogen in women.

Qualifications:

• Postmenopausal women between the age of 50-65 years

• Non-smokers

• Volunteers should NOT currently be taking Birth Control. Hormone Replacement Therapy (HRT), cholesterol or blood pressure lowering medication or exercising vigorously more than two days per week.

Benefits for study volunteers include:

• Ultrasound of the blood vessels and heart

• Blood cholesterol profile

• Comprehensive dietary analyses

• Measurements of bone mineral density and body composition

• Compensation for your time

COMIRB 07-1097. Principal Investigator: Kerrie Moreau, PhD. To participate contact: chelsea.bergman@ucdenver.edu or call 720-848-6475.

Men, women between 60-75 sought for exercise study

(July 9, 2009) The University of Colorado Denver seeks healthy Women and Men between the ages of 60-75 to be in an exercise research study, Myogenic and Osteogenic responses to eXercise and Ibuprofen (MOXI).

To participate in this study you must be:

• a woman or man in generally good health

• 60 – 75 years of age

• not lifting weights regularly but willing to start

• not using aspirin, ibuprofen or similar drugs more than two days a month

Eligible women and men will receive at no cost:

• health screening tests

• a personalized and supervised exercise program

Goal:

We are looking at the effects of the pain reliever ibuprofen on changes in muscle and bone due to exercise in older adults.

Initial screening tests include:

• a physical exam

• bone density scan

• treadmill exercise test

• blood tests

Women and men who qualify will begin planned exercise training for 9 months at our exercise facility. Participants will take ibuprofen or an inactive pill (placebo) on the days they exercise. This study is funded by the National Institutes of Health. Monetary compensation provided.

Location: Anschutz Medical Campus in Aurora.

Contact Marsha at 720.848.6461 or GIM.MOXIstudy@ucdenver.edu. PI: Wendy Kohrt, PhD. COMIRB #06-0769.

Exercise and hormone replacement

(June 9, 2009) Healthy, postmenopausal women between the ages of 45-65 years are need for a study that will explore exercise and hormone replacement therapy (HRT).

The purpose of this study is to investigate the impact Hormone Replacement Therapy (HRT) and Exercise on cardiovascular health.

Qualifications:

• Postmenopausal women between the age of 45-65 years

• Non-smokers

• Volunteers should not currently be taking HRT or exercising vigorously more than two days a week.

Benefits for study volunteers include:

• Physician supervised exercise stress test

• Ultrasound of the blood vessels

• Individual exercise program

• Comprehensive dietary analyses

• Measurements of bone mineral density and body composition

• Compensation for your time

If you are interested in participating, contact Chelsea Bergman at 720-848-6475 or Chelsea.Bergman@ucdenver.edu. COMIRB No. 05-0606

Men over 50 sought for weight training

(June 3, 2009) The University of Colorado Denver is looking for healthy men, age 50 and older, to be in a musculoskeletal responses to acetaminophen and exercise training study.

To participate in this study you must be:

• a man in generally good health

• 50 years or older

• a non-smoker

• not exercising regularly but willing to start

Eligible men will receive at no cost:

• health screening tests

• a personalized and supervised exercise program

Goal of the Study: We are looking at the effects of two pain relievers, acetaminophen and ibuprofen, on changes in muscle and bone due to exercise.

Outline of the Study: Initial screening tests include a physical exam, bone density scan, treadmill exercise test and blood tests. Men who qualify will begin planned exercise training for nine months at our exercise facility on the Anschutz Medical Campus. Participants will take ibuprofen, acetaminophen, or an inactive pill (placebo) on the days they exercise. Muscle biopsies will take place three times.

This study is funded by the National Institute on Aging. PI: Catherine Jankowski, PhD. COMIRB #06-0343. Contact Marsha at 720.848.6481 or Mr-acetstudy@ucdenver.edu.  

Men over 40 needed for joint study

(March 23, 2009) Men 40 years or older are needed to participate in a research study on joint laxity and its relationship to blood hormone levels.

Men between 40-80 years of age who have never had an injury or diagnosis of arthritis at the base of your thumb are encouraged to take part.

Volunteers will have a single blood draw, an X-Ray of both hands, an examination of joint laxity and will complete questionnaires.

Monetary compensation will be provided for your time. If interested, contact Jon Rutigliano at 303-724-1588 or at Jonathan.Rutigliano@ucdenver.edu. COMIRB No: 08-0167

Volunteers with mild memory impairment needed

(March 23, 2009) We are looking for volunteers for a study of visual perception.

Eligible subjects will have mild memory impairment or early Alzheimer’s disease and be between 50 – 95 years of age.

Subjects are not eligible to participate if they have had a brain injury, stroke or brain disorder other than mild memory impairment or early Alzheimer’s disease.

The goal of the study is to find a visual perception marker of preclinical Alzheimer’s disease in subjects with mild memory impairment.

Subjects will undergo:

1.  visual screening,
2. a neurologic evaluation,
3. be asked to judge images presented in 3D using virtual reality techniques during a total of 3-in-person visits.

There will be no monetary compensation for participating. The study is sponsored by the Alzheimer’s Association. Contact Barby Halliday, PRA at 303 724 4717 or barbetta.halliday@uchsc.edu for more information. PI: Victoria S. Pelak, MD, COMIRB #05-1131.

‘Testosterone, Exercise in Aging Men ’ volunteers needed

(Feb. 24, 2008) The Division of Geriatrics Medicine at UC Denver is looking for older male volunteers to take part in a testosterone (male hormone) and exercise training study that focuses on the effects of testosterone supplementation on physical and functional performance.

Study qualifications:

• Male 60 years or older, in good general health

• You should not have a present history of testosterone supplementation

• You should not have a present or past history of prostate or breast cancer,

• You should not be participating in an strength training program 3 or more days per week

• Be able to read and understand English

If you qualify you will receive:

• Physical examination

• Laboratory testing

Financial compensation is available for active participants. For more information about the TEAM study, contact Bethany Kelsey, study coordinator at 720-848-6399 or Bethany.kelsey@ucdenver.edu. PI: Robert S. Schwartz, MD, COMIRB No. 02-1056.

Healthy, postmenopausal women for estrogen, cortisol and exercise study

(Jan. 19, 2009) Volunteers needed:

• Healthy, postmenopausal women

• Age 40-59

• Overweight to obese (BMI 25-39)

• No current use of hormone therapy

• Non-smoking

• Ability and willingness to take part in a 7-month study that will consist of screening tests, one month wearing either an estrogen or inactive (placebo) patch, 4 months supervised exercise program to lose weight, and follow-up testing.

Measurements and study procedures for volunteers include:

• Measurement of body composition and bone density

• Screening for diabetes

• Fitness testing

• Personalized exercise program

• Fat biopsies

Compensation will be provided. If you are interested in participating contact Kelli McCall at (303) 848-6418 or Kelli.McCall@UCDenver.edu.

COMIRB #07-0278. Principal Investigator: Wendee Gozansky, MD, MPH

Research on minimally invasive total knee replacement

(Jan. 15, 2009) Volunteers between the ages of 50 and 85 years are invited to participate in a research study that will evaluate whether minimally invasive total knee replacements (TKR) improve muscle function compared to traditional TKR. Potential volunteers must have osteoarthritis and be candidates for a TKR.

Volunteers will be asked to participate in 6 sessions over 1 year, each lasting about 1 hour. In addition, research staff will aid in coordinating physical therapy with therapists using a progressive exercise program, at no extra cost to the patient. Financial compensation is available for participation in this research study. If you are interested in participating or would like to receive additional information, contact the Muscle Performance Lab in the Physical Therapy Program, University of Colorado Denver at (303)724-9590 or TKA.Study@ucdenver.edu. (Principle Investigator, Jennifer Stevens, MD, COMIRB Protocol #06-0183.

Memory function research

(Nov. 4, 2008) Volunteers are needed for a research study to determine whether six months of exercise training or a study drug (Pioglitazone) can improve memory function. 

Participants must be women and men who:

1. are over 55 years of age
2. have mild memory problems
3. are slightly overweight
4. may have “pre-diabetes”
5. are not using hormone therapy
6. are non-smokers
7. are not regularly exercising

Participants will receive at no cost information regarding their health status, including testing for memory function, diabetes, cholesterol, body fat and bone density. Eligible participants will also receive monetary compensation.

 For more information, contact Erica Borresen at720-848-6376 or email erica.borresen@ucdenver.edu. Principal Investigator: Robert S. Schwartz, MD; COMIRB # 07-1215