Exercise and ibuprofen in older adults
(Sept. 18, 2008) Volunteers are needed for a research studying examining the effects of the pain reliever ibuprofen on changes in muscle and bone due to exercise in older adults.
Participants must be:
- male or female in general good health
- 60-75 years of age
- not lifting weights regularly but willing to start
- not using aspirin, ibuprofen or similar drugs more than two days per month
Eligible participants will receive:
- health screening tests
- a personalized and supervised exercise program
- monetary compensation
Initial screening tests include a physical exam, bone density scan, treadmill exercise test and blood tests. Subjects will begin planned exercise training for nine months at study facilities. Participants will take ibuprofen or an inactive pill (placebo) on the days they exercise. This study is funded by the National Institutes of Health.
For more information, contact Marsha at 720-848-6461 or marsha.steirn@uchsc.edu. Principal Investigator: Wendy Kohrt, PhD; COMIRB #06-0769
Irritable bowel syndrome
(Sept. 15, 2008) Overweight people who suffer from irritable bowel syndrome are encouraged to enroll in a research study that examines the impact of a low-carbohydrate (Atkins) diet on the syndrome.
Participants will be paid for completing the study and will receive all meals free for six weeks.
Participants must:
- be 18-70 years old, male or female
- have diarrhea-predominant Irritable Bowel Syndrome
- be overweight
- desire to use the Atkins Diet for possible weight loss be in stable health
Principle investigator Dr. Gregory Austin; COMIRB Study No. 07-0799
Contact Nicole Jacobson at Nicole.Jacobson@UCDenver.edu to learn more about the study and whether you might qualify.
Bulimia Nervosa or Binge Eating Disorder
(Aug. 22, 2008) People who suffer from Bulimia Nervosa or Binge Eating Disorder may be able to help with a Research Study of Taste and Monetary Reward and Brain Response. The study aims to examine reward learning and brain response/activation to taste and monetary reward learning tasks using fMRI technology.
We are looking for:
- Females with Bulimia Nervosa or Binge Eating Disorder
- 16-45 years old
- Without permanent metal implants in the body or metal braces/retainers
- Who are right handed
- Who are not pregnant
Participants will:
- Complete a comprehensive psychiatric screening
- Fill out self assessment questionnaires
- Taste test various sugar solutions for their sweetness and pleasantness
- Complete two tasks during a brain imaging scan
- While in the fMRI scanner, participants will receive small amounts of sweet or tasteless solutions through a mouthpiece
- They will also play a computer game where they try to figure out how to earn money Participants will be compensated for time and travel
Contact Leah Jappe 720-777-4026 or Leah.Jappe@UCHSC.edu. Principal Investigator: Guido K.W. Frank, MD, COMIRB #07-0816.
Subjects needed for exercise metabolism research
(July 18, 2008) Participants are needed for a three-part, metabolism study investigating how fat stored in muscles affects insulin activity.
Participant requirements:
- sedentary man or woman (women volunteers should not be using oral contraceptives)
- 30-50 years of age
- non-smoker
- no history of hyperlipidemia
- doctor has not advised against exercising
Two different preliminary assessments will measure:
- body fat content
- maximal exercise capacity (VO2max)
- heart rhythm
- resting metabolic rate
- glucose tolerance
- blood tests
- health and physical examination performed by a physician
The third visit will be a metabolic study day, during which the following will occur:
- 12-hour fast
- infusion of naturally occurring tracer of carbohydrate and fat through an intravenous catheter
- blood sampling from a catheter placed in a hand vein
- 3 muscle biopsies
- 1.5 hours of exercise at 45 percent of maximal capacity, before and after periods of rest
Diet will be controlled for 3 days before each study day. All three visits will be performed at the General Clinical Research Center. Compensation will be provided.
For more information about this study, call Devon at 303-724-3968.
P.I. Dr. Bryan Bergman. COMIRB # 03-398
Metabolism and heart healthy study
(July 17, 2008) Participants are need for a study of the effects of fats in the blood on the heart, blood vessels and the ability to exercise.
You may be eligible to participate in this study if:
- you are 18-40 years of age
- normal weight
- you exercise vigorously less than twice a week
- you do not have diabetes or heart, liver or kidney disease
- you have normal blood pressure
The study includes:
- physical exam, blood draws and activity questionnaire
- assessment of body composition, insulin sensitivity, blood vessel function, cardiac function and exercise capacity
- repetition of these tests after infusion of a standard intravenous nutritional supplement
Compensation will be provided. To learn more about the study, contact Leah Herlache, MS, at 720-848-6688 or Leah.herlache@uchsc.edu.
COMIRB # 04-0071. Principal Investigator: Jane Reusch, MD
Maternal weight during pregnancy study
(July 17, 2008) Participants are need for a study to explore dietary habits and blood glucose profiles in pregnant women.
Participant requirements:
- healthy females, less than 15 weeks pregnant
- between the ages of 18-35
- no prior history of diabetes
- body Mass Index (BMI) of 30-40 (to determine BMI, visit http://nhlbisupport.com/bmi/)
- willing to attend six visits for study related materials
Participants will receive at no cost:
- dietary analysis and counseling
- laboratory testing
- resting metabolic rate measurement
- financial compensation
For more information, contact pregnancy study at 303-315-9089 or elizabeth.kealey@uchsc.edu.
COMIRB 05-1134. Co-Investigator: Kristin Harmon, MD
Metabolic research study in males
(July 10, 2008) Subjects are needed for a study to determine the effects of diet and exercise on fat metabolism.
Participants must meet the following requirements:
- male
- non-smoking
- exercise less than 2 hours per week
- body mass index (BMI) of less than 25 or greater than 30 (to determine your BMI, visit http://www.nhlbisupport.com/bmi/)
Volunteers will receive:
- assessment of cariovoascular fitness and cholesterol
- body composition assessment
- nutritional analysis
- monetary compensation
For more information, send an e-mail to flex@uchsc.edu or contact the Center for Human Nutrition Study Recruitment Line at 303-315-4087 and press option 2 for the FLEX study. Principal Investigator: Edward Melanson, PhD. COMIRB #05-1117
Dietary Restriction vs. Intermittent Fasting (DRIFT) study
(July 9, 2008) Participants are needed for the Dietary Restriction versus Intermittent Fasting (DRIFT) study. The purpose of the study is to compare two different diet methods; a normal, low-calorie diet and fasting every other day.
Requirements to participate
- obese females (who are not pregnant or breastfeeding) or obese males
- between 18-55 years of age
- non-smoker
- body mass index (BMI) greater than 30 (to determine your BMI, visit http://www.nhlbisupport.com/bmi/)
Participants will receive
- an 8-week supervised weight loss program
- free meals during the diet
- assessment of cardiovascular fitness and cholesterol
- body composition assessment
- nutritional analysis
- monetary compensation
For more information, send an email to drift@uchsc.edu or contact the Center for Human Nutrition Study Recruitment Line at 303-315-4087, and press option one for the DRIFT study.
Principal Investigator: Edward Melanson, PhD COMIRB #06-0383
'Choose to Lose' six-month weight loss study
(July 17, 2008) Obese people in generally good health are encouraged to participate in a 6-month weight loss study at the Center for Human Nutrition. The study will use two medications in combination or alone. Participants will receive medical evaluations, nutrition and lifestyle counseling, investigational medications and compensation.
Qualified people include:
- 18-65 years old in generally good health
- Obese (BMI 27-45, check your BMI at http://www.nhlbisupport.com/bmi)
- Not taking antidepressants
- Relatively stable weight
- Nonsmoker
- Non-diabetic
Call 303-315-9101 for more information. PI: Holly Wyatt, MD. COMIRB protocol No. 08-0482.
Prevention of obesity in women
(June 25, 2008) The UC Denver IMAGE Research Group at Anschutz Medical Campus is looking for healthy young women to participate in a research study on the Prevention of Obesity in Women via Estradiol Regulation (POWER).
Participants must be:
Benefits for study volunteers include:
-
Measurement of body composition and bone density
-
Fitness testing
-
Comprehensive diet analysis
-
Personalized and supervised exercise program
Compensation will be provided for time.
Those interested in participating in the POWER study can contact Ellie Gibbons at 720-848-6408 or
Ellie.Gibbons@UCHSC.EDU